Griffith was 5-for-8 shots from the field, including a 4-for-7 performance from 3-point range, and had three steals as the Wildcats (11-1) won for the second time in two nights.
Tournament MVP Tatum Brown added 15 points and 14 rebounds, and Angela Lackey had 11 points.
Jill Morton led Louisville (7-4) with 25 points, hitting 6-of-9 3-pointers. Kara Kessans added 13 points, and Jenny Knight had eight assists.
Arizona held the Cardinals to 25 percent shooting (8-of-32) in the first half. The Wildcats also scored 17 points on 14 Louisville free throws and outrebounded the Cardinals 41-33.
Tied at 32 at halftime, Arizona shot 62 percent (13-of-21) and made 17-of-23 free throws in the second half.